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MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. PDF available through Get Fulltext Research

Lee, Kyung Yong Im, Jun-Sub Shibata, Etsuko Park, Jonghoon Handa, Naofumi Kowalczykowski, Stephen C Dutta, Anindya

Published in Nature communications

MCM8-9 complex is required for homologous recombination (HR)-mediated repair of double-strand breaks (DSBs). Here we report that MCM8-9 is required for DNA resection by MRN (MRE11-RAD50-NBS1) at DSBs to generate ssDNA. MCM8-9 interacts with MRN and is required for the nuclease activity and stable association of MRN with DSBs. The ATPase motifs of M...

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