Kowalczykowski Lab - UC Davis

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Decatenation of DNA by the S. cerevisiae Sgs1-Top3-Rmi1 and RPA complex: a mechanism for disentangling chromosomes. PDF available through Get Fulltext Research

Cejka, Petr Plank, Jody L Dombrowski, Christopher C Kowalczykowski, Stephen C

Published in Molecular cell

Genetic evidence indicates that Saccharomyces cerevisiae Sgs1, Top3, and Rmi1 resolve topologically linked intermediates arising from DNA replication and recombination. Using purified proteins, we show that Sgs1, Top3, Rmi1, and replication protein A (RPA) coordinate catenation and decatenation of dsDNA through sequential passage of single strands ...

Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. PDF available through Get Fulltext Research

Ciccia, Alberto Nimonkar, Amitabh V Hu, Yiduo Hajdu, Ildiko Achar, Yathish Jagadheesh Izhar, Lior Petit, Sarah A Adamson, Britt Yoon, John C Kowalczykowski, Stephen C ...

Published in Molecular cell

Completion of DNA replication after replication stress depends on PCNA, which undergoes monoubiquitination to stimulate direct bypass of DNA lesions by specialized DNA polymerases or is polyubiquitinated to promote recombination-dependent DNA synthesis across DNA lesions by template switching mechanisms. Here we report that the ZRANB3 translocase, ...

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